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探究了稀土、水杨酸(Hsal)与8-羟基喹啉(Hhq)的三元配合物RE(sal)2hq(RE=Pr、Gd、Er)对红酵母生命活性的影响。采用杯碟法,通过测量抑菌圈直径研究了配合物的抑菌能力,再利用二倍稀释法确定了其最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。结果表明,配体水杨酸(Hsal)没有抑菌效果,8-羟基喹啉(Hhq)抑菌能力强。当抑菌作用不明显的稀土(RE=Pr、Gd、Er)离子与其配体形成三元配合物后,抑菌能力明显得到增强。配合物Pr(sal)2hq、Gd(sal)2hq、Er(sal)2hq和配体8-羟基喹啉的MIC分别位于1 mmol.L-1～2 mmol.L-1、0.5 mmol.L-1～1 mmol.L-1、0.5 mmol.L-1～1 mmol.L-1和2 mmol.L-1～3 mmol.L-1;MBC分别为2 mmol.L-1、2 mmol.L-1、2 mmol.L-1和4 mmol.L-1。初步推测三种稀土水杨酸8-羟基喹啉三元配合物可以作为药物应用于有害红酵母的生物防治中。
The effect of the RE (sal) 2hq (RE = Pr, Gd, Er), a ternary complex of rare earth, salicylic acid (Hsal) and 8- hydroxyquinoline (Hhq) The antibacterial ability of the complex was studied by measuring the diameter of the zone of inhibition using the cup-plate method. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the complex were determined by double dilution method. The results showed that Hsal had no antibacterial activity and Hhq exhibited strong antibacterial activity. When the antibacterial effect of rare earth (RE = Pr, Gd, Er) ions formed a ternary complex with its ligand, the antibacterial ability was significantly enhanced. The MICs of the complexes Pr (sal) 2hq, Gd (sal) 2hq, Er (sal) 2hq and ligand 8-hydroxyquinoline were 1 mmol.L-1 ~ 2 mmol.L-1, 1 to 1 mmol.L-1, 0.5 mmol.L-1 to 1 mmol.L-1 and 2 mmol.L-1 to 3 mmol.L-1; MBC was 2 mmol.L-1 and 2 mmol, respectively. L-1, 2 mmol.L-1 and 4 mmol.L-1. Preliminary speculation that three kinds of rare earth salicylic acid 8-hydroxyquinoline ternary complexes can be used as a drug in the biological control of harmful red yeast.