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冠状动脉粥样斑块破裂后阻塞冠状动脉血管是急性心肌梗死主要发病机制。以往血管影像学和病理学研究认为斑块破裂是自发性或继发性因素作用于局部单个冠状动脉斑块,而病理生理学研究认为在炎症。交感神经张力、儿茶酚胺等多种因素影响下冠状动脉内可形成多个不稳定性斑块。作者通过血管造影证实急性透壁性心肌梗死病人存在多发性冠状动脉斑块,并测定其对临床结果的影响。
Coronary artery plaque rupture after coronary artery is the main pathogenesis of acute myocardial infarction. Previous vascular imaging and pathological studies suggest that plaque rupture is a spontaneous or secondary factor acting on localized single coronary plaque, whereas pathophysiological studies suggest inflammation. Sympathetic tone, catecholamines and other factors under the influence of coronary artery can form a number of unstable plaques. The authors confirmed the presence of multiple coronary plaques in patients with acute transmural myocardial infarction by angiography and determined their effect on clinical outcomes.