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目的:观察国产多烯紫杉醇(艾素)联合顺铂治疗晚期乳腺癌的疗效及毒副反应。方法:21例患者均有病理学诊断及可评价的客观指标。采用多烯紫杉醇35mg/m2,静脉滴注1h,第1天、第8天及第15天,顺铂(DDP)为30mg/m2静脉滴注,第2天、第3天及第4天,28d为1个周期,所有患者均至少接受2个周期的化疗。结果:完全缓解(CR)1例,部分缓解(PR)11例,总有效率57.14%。主要毒副反应为骨髓抑制和脱发。结论:多烯紫杉醇联合顺铂治疗晚期乳腺癌有效率较高,毒副反应较小,值得临床进一步研究。
Objective: To observe the curative effect and toxicity of domestic docetaxel combined with cisplatin in the treatment of advanced breast cancer. Methods: All the 21 patients had pathological diagnosis and objective evaluation. Intravenous infusion of docetaxel 35mg / m2, intravenous infusion 1h, day 1, day 8 and day 15, cisplatin (DDP) 30mg / m2 intravenous infusion, the first two days, three days and four days, 28d for a cycle, all patients received at least 2 cycles of chemotherapy. Results: Complete remission (CR) in 1 case, partial remission (PR) in 11 cases, the total effective rate was 57.14%. The main side effects are myelosuppression and hair loss. Conclusions: Docetaxel combined with cisplatin in the treatment of advanced breast cancer is more effective and has fewer toxic and side effects, which deserves clinical further study.