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目的探讨P300靶刺激中的P3波用于评估皮质下缺血性血管认知功能障碍(VCI)的价值。方法测试皮质下缺血性血管病患者痴呆(SIVD)组43例、非痴呆的认知功能障碍(VCND)组34例与认知正常组38例P3波潜伏期和波幅的变化。结果在Cz和Pz区域,与正常对照组比较,SIVD组的潜伏期[(400.43±3.57)ms、(309.76±3.96)ms]明显延长(P﹤0.05),波幅[(4.23±0.34)μV、(5.87±1.54)μV]明显降低(P﹤0.05)。在Cz和Pz区域,VCND组的潜伏期[(400.26±5.55)ms、(396.12±5.23)ms]较正常对照组均明显延长(P﹤0.05);而波幅[(18.22±0.29)μV、(8.85±0.2)μV]较正常对照组在Cz区域明显降低(P﹤0.05),但在Pz区域无显著性差异。结论P3波可作为诊断SIVD的重要客观指标;P3波潜伏期作为皮质下缺血性VCND的辅助诊断指标可能更为敏感。
Objective To investigate the value of P3 wave in P300 target stimulation for the assessment of subcortical ischemic vascular cognitive impairment (VCI). Methods The changes of P3 wave latency and amplitude in 43 patients with dementia with subcortical ischemic vascular disease (SIVD), 34 patients with dementia without cognitive impairment (VCND) and 38 patients with cognitive impairment were studied. Results In the Cz and Pz regions, the latency of SIVD group was significantly longer than that of the control group [(400.43 ± 3.57) ms, (309.76 ± 3.96) ms], amplitude [(4.23 ± 0.34) μV, 5.87 ± 1.54) μV] was significantly lower (P <0.05). In the Cz and Pz regions, the latency of the VCND group was significantly longer than that of the normal control group [(400.26 ± 5.55) ms, (396.12 ± 5.23) ms vs (8.82 ± 0.29) μV, ± 0.2) μV] in the Cz region was significantly lower than that in the normal control group (P <0.05), but there was no significant difference in the Pz region. Conclusions P3 wave can be used as an important objective index in the diagnosis of SIVD. P3 wave latency may be more sensitive as an auxiliary diagnostic indicator of subcortical ischemic VCND.