论文部分内容阅读
目的:了解血清C反应蛋白(CRP)水平与冠心病(CHD)患者冠状动脉斑块形态的关系,从临床角度探讨斑块破裂的原因。方法:根据冠状动脉造影结果将56例CHD患者按动脉粥样斑块进行形态学分型分为:I型亚组(18例),Ⅱ型亚组(22例),Ⅲ型亚组(16例),另选冠状动脉正常者20例作对照。检测所有入选者血清CRP及心脏肌钙蛋白T(cTnT)水平,比较各组间的差异。结果:Ⅱ型亚组CRP水平最高[(7.2±1.0)mg/L],Ⅲ型、Ⅰ型亚组及冠状动脉正常组依次减低[分别为(4.5±1.0)、(3.7±0.8)、(1.6±0.3)mg/L]。结论:血清CRP水平与冠状动脉病变程度密切相关,而反映斑块不稳定的Ⅱ型斑块的血清CRP水平明显增高,从临床角度提示局部炎症反应是导致斑块破裂的原因。
Objective: To investigate the relationship between serum C-reactive protein (CRP) level and coronary plaque morphology in patients with coronary heart disease (CHD) and to explore the causes of plaque rupture from a clinical perspective. Methods: Fifty-six patients with CHD were divided into atherosclerotic plaques according to the results of coronary angiography. Type I subgroups (18 cases), type II subgroups (22 cases), type III subgroups (16 cases ), Another 20 cases of normal coronary artery as a control. The levels of serum CRP and cardiac troponin T (cTnT) in all the patients were detected, and the differences among the groups were compared. Results: The highest level of CRP in type Ⅱ subgroup was [(7.2 ± 1.0) mg / L], the level of type Ⅲ subtype and type Ⅰ subgroup were lower than those in normal group [(4.5 ± 1.0), (3.7 ± 0.8) and 1.6 ± 0.3) mg / L]. CONCLUSION: Serum CRP levels are closely related to the degree of coronary artery lesion. Serum CRP levels in type Ⅱ plaques, which reflect unstable plaque, are significantly increased. It is suggested from the clinical point of view that local inflammatory response is the cause of plaque rupture.