早在1878年就有人提出“受体”假说,本世纪初有人经过药理实验和动物实验,分别论证了受体假说的正确性。但由于受实验技术和条件的限制,受体的研究几乎完全限于间接的药理学研究。本世纪六十年代以后,随着放射性配基技术和亚细胞成分的分离提纯技术的稳步发展,多种受体的分离和定性研究获得了很大的进展,部分受体如 N-胆碱受 As early as 1878, some people proposed the “receptor” hypothesis. At the beginning of this century, some people conducted pharmacological experiments and animal experiments to prove the correctness of the receptor hypothesis. However, due to experimental techniques and conditions, receptor studies are almost entirely limited to indirect pharmacological studies. Since the 1960s, with the steady development of radio-ligand technology and the separation and purification of subcellular components, great progress has been made in the isolation and qualitative research of various receptors. Some receptors such as N-choline