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[目的]探讨血清OPG水平在正常妊娠及子痫前期孕妇中的变化。[方法]选择2008年11月～2009年7月在某院产科就诊的正常妊娠妇女89例和子痫前期患者63例(轻度28例,重度35例)。采用酶联免疫吸附方法(ELISA)检测血清OPG水平。采用方差分析、t检验等方法比较各组间血清OPG的水平及其与血压、24h尿蛋白的关系。[结果]正常妊娠时,孕妇血清OPG水平随妊娠进展逐渐升高,在孕晚期达高峰;孕晚期血清OPG水平与孕中期及孕早期相比较,差异均有统计学意义;重度子痫前期组血清OPG水平显著低于轻度子痫前期及正常晚期妊娠组,且患者血清OPG水平与抽血时收缩压呈负相关。[结论]重度子痫前期患者存在血清OPG水平的异常。OPG的异常可能与子痫前期的发病机制有关。
[Objective] To investigate the changes of serum OPG levels in normal pregnant women and pregnant women with preeclampsia. [Methods] 89 cases of normal pregnant women and 63 cases of preeclampsia (mild 28 cases, severe 35 cases) were selected from November 2008 to July 2009 in obstetrics and gynecology department of a hospital. Serum OPG levels were measured by enzyme-linked immunosorbent assay (ELISA). ANOVA and t-test were used to compare the serum levels of OPG and blood pressure and 24h urine protein. [Results] The level of serum OPG in normal pregnant women increased gradually with the progress of pregnancy and reached the peak in the third trimester of pregnancy. The serum OPG level in the third trimester of pregnant women was significantly different from that in the second trimester and the first trimester. The severe preeclampsia group Serum OPG levels were significantly lower than those in mild preeclampsia and normal late pregnancy, and serum OPG levels were negatively correlated with systolic blood pressure when blood was drawn. [Conclusion] Serum OPG levels are abnormal in patients with severe preeclampsia. Abnormalities in OPG may be related to the pathogenesis of preeclampsia.