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目的研究替罗非班在急性ST段抬高心肌梗死介入手术中效果。方法 86例急性ST段抬高心肌梗死患者,随机分为对照组和实验组,每组43例。对照组给予经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI),急诊介入术治疗,实验组在对照组的基础上静脉推注替罗非班注射液。比较两组患者手术120 min后心电图ST段回落总有效率、心肌成色Ⅲ级百分比、左心射血分数、出血并发症及不良心血管事件发生率。结果实验组总有效率为90.7%,对照组总有效率为74.4%,在心肌成色Ⅲ级百分比、左心射血分数、不良心血管事件发生率上差异均具有统计学意义(P<0.05);出血并发症发生率对照组低于实验组(P<0.05)。结论替罗非班用于急性ST段抬高心肌梗死急诊介入术能有效提高心电图ST段回落百分比,疗效显著,值得临床推广。
Objective To study the effect of tirofiban in the interventional treatment of acute ST-segment elevation myocardial infarction. Methods A total of 86 patients with acute ST-segment elevation myocardial infarction were randomly divided into control group and experimental group, with 43 cases in each group. The control group received percutaneous coronary intervention (PCI) and emergency intervention. The experimental group was given intravenous tirofiban injection on the basis of the control group. The total effective rate of ST-segment depression, grade Ⅲ myocardial grade, left ventricular ejection fraction, bleeding complications and incidence of adverse cardiovascular events were compared between the two groups after 120 min of operation. Results The total effective rate was 90.7% in the experimental group and 74.4% in the control group. There was significant difference in the percentage of grade Ⅲ, left ventricular ejection fraction and adverse cardiovascular events in the experimental group (P <0.05) The incidence of bleeding complication in the control group was lower than that in the experimental group (P <0.05). Conclusion The use of tirofiban for acute ST-segment elevation myocardial infarction intervention can effectively improve the percentage of ST-segment depression in ECG. The effect is significant and worthy of clinical promotion.