呼吸道粘膜纤毛系统的清洁作用是人体呼吸道重要的保护功能,它通过纤毛输送的形式将吸入的有害物质排出体外。临床研究已经表明,如果纤毛输送功能发生障碍,就很难避免呼吸道疾病、尤其是感染性疾病的发生。本文将系统地阐述纤毛研究的进展、目前研究的趋势以及对今后研究方向的展望。 1 呼吸道粘膜纤毛系统研究的里程碑早在1683年,意大利人Antonio de Heide首次描述了纤毛的运动。但在将近一百年后的1773年才由德国人Müller将其命名为“纤毛”。1830年,英国的科学家Purkinje和 Respiratory mucosal ciliary system cleaning is an important protective function of the human respiratory tract, it is in the form of ciliary transport of inhaled harmful substances excreted. Clinical studies have shown that if ciliary dysfunction occurs, it is difficult to avoid respiratory diseases, especially infectious diseases. This article systematically expresses the progress of cilia research, current research trends and future research directions. Milestone in the study of the respiratory mucosal cilia system As early as 1683, the Italian Antonio de Heide first described the movement of the cilia. But almost a century later, in 1773, it was named “cilia” by German Müller. In 1830, British scientists Purkinje and