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汉坦病毒是分节段病毒,其基因组核酸由三段负链RNA组成,即大(L)、中(M)和小(S)3个片段。引起流行性出血热(HFRS)。S片段编码核衣壳蛋白(NP),其在病毒颗粒中含量高,免疫原性强,是HFRS的理想诊断抗原。国内外对S基因分别在原核系统杆状病毒系统和痘苗病毒中进行了表达和初步应用[
Hantaan virus is a segmented virus whose genomic nucleic acid consists of three negative-stranded RNAs, namely three large (L), medium (M) and small (S) fragments. Cause epidemic hemorrhagic fever (HFRS). S fragment encodes the nucleocapsid protein (NP), which is high in viral particles and strong in immunogenicity and is an ideal diagnostic antigen for HFRS. S gene at home and abroad in the prokaryotic baculovirus system and vaccinia were expressed and preliminary application [