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1例26岁女性因甲状腺功能亢进症口服甲巯咪唑20 mg、2次/d。1个多月后出现四肢肌肉痉挛性疼痛。实验室检查：丙氨酸转氨酶（ALT） 45 U/L，天冬氨酸转氨酶（AST） 121 U/L，肌酸激酶（CK）6 090 U/L，血钾4.1 mmol/L。甲巯咪唑剂量减至10 mg、1次/d，3 d后患者肌痛仍无好转。考虑为甲巯咪唑所致不良反应，遂停药。停药4 d后，患者肌痛明显缓解，实验室检查：ALT 36 U/L，AST 50 U/L，CK 1 954 U/L。停药18 d后，患者肌痛消失，ALT、AST和CK均恢复正常。“,”A 26-year-old female patient took oral methimazole 20 mg twice daily due to hyperthyroidism. More than a month later, she developed spastic pain of limb muscles. Laboratory tests showed alanine aminotransferase (ALT) 45 U/L, aspartate aminotransferase (AST) 121 U/L, creatine kinase (CK) 6 090 U/L, and serum potassium 4.1 mmol/L. The dose of methimazole was reduced to 10 mg once daily, but the patient′s myalgia was not improved after 3 days. Adverse reactions due to methimazole were considered and therefore the drug was discontinued. Four days after drug withdrawal, the patient′s myalgia was obviously relieved, and laboratory tests showed ALT 36 U/L, AST 50 U/L, and CK 1 954 U/L. After 18 days of drug withdrawal, her myalgia disappeared, and the ALT, AST, and CK returned to normal.