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目的:探讨地塞米松(DEX)对脑膜炎家兔脑脊液(CSF)中可溶性细胞间黏附分子-1(sICAM-1)质量浓度变化的影响,为临床应用DEX辅助治疗脑膜炎提供理论依据。方法:家兔36只,随机分为模型组、地塞米松处理组和对照组;不同时点采集其脑脊液,采用ELISA法检测CSF中sICAM-1质量浓度。结果:模型组CSF sI-CAM-1质量浓度明显高于对照组同时相,差异有统计学意义(P均<0.01);脑组织含水量高于对照组,差异有统计学意义(P<0.01)。地塞米松处理组CSF sICAM-1质量浓度低于模型组同时相,差异有统计学意义(P均<0.05),脑组织含水量低于模型组,差异有统计学意义(P<0.05)。结论:细菌性脑膜炎(BM)病程中sICAM-1分泌增多,细胞间黏附分子-1(ICAM-1)参与脑水肿形成;DEX通过抑制ICAM-1表达和(或)分泌,而减轻血脑屏障损害,减轻脑水肿形成。
Objective: To investigate the effect of dexamethasone (DEX) on the changes of soluble intercellular adhesion molecule-1 (sICAM-1) in cerebrospinal fluid (CSF) of meningitis in rabbits and to provide a theoretical basis for the clinical application of DEX in the treatment of meningitis. Methods: Thirty-six rabbits were randomly divided into model group, dexamethasone group and control group. Cerebrospinal fluid (CSF) was collected at different time points. The concentration of sICAM-1 in CSF was measured by ELISA. Results: The CSF sI-CAM-1 concentration in the model group was significantly higher than that in the control group (P <0.01), and the water content in the brain tissue was higher than that in the control group (P <0.01) ). The concentration of CSF sICAM-1 in dexamethasone group was lower than that in model group (P <0.05), and the water content in brain tissue was lower than that in model group (P <0.05). CONCLUSIONS: The increase of sICAM-1 secretion during the course of bacterial meningitis (BM) and the intercellular adhesion molecule-1 (ICAM-1) are involved in the formation of cerebral edema. DEX can reduce the expression of ICAM-1 and / Barrier damage, reduce brain edema formation.