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当使用大剂量或超剂量维生素B_6(VB_6)对抗异烟肼、肼和毒蘑菇中毒,或长期口服大剂量VB_6治疗腕管综合征、高胱氨酸尿、高草酸盐尿等疾病时,有少数病例出现VB_6的不良反应,主要为周围感觉神经病变。个体对VB_6的耐受性有差异。若需长期口服,认为剂量低于500mg/d是安全的。为防止大剂量、长时期服VB_6引起的不良反应,应加强对服药者临床症状观察,重点为感觉神经病变引起的感觉异常。
When using large dose or over dose of vitamin B_6 (VB_6) against isoniazid, hydrazine and poisonous mushroom poisoning, or long-term oral administration of large doses of VB_6 treatment of carpal tunnel syndrome, homocystinuria, oxalate and other diseases, A small number of cases of adverse reactions occurred VB_6, mainly peripheral sensory neuropathy. Individuals have different tolerance to VB_6. If long-term oral administration, that the dose below 500mg / d is safe. In order to prevent large doses, long-term service adverse reactions caused by VB_6, should be to enhance the clinical symptoms observed medication, focusing on sensory neuropathy caused by abnormal sensations.