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126例伴有全身表现的急性下呼吸道感染患者随机分为两组。A组每天服用480mg磺胺增效剂和2,400mg磺胺甲基异恶唑(每12小时3片),而B组每6小时服用盐酸四环素500mg。治疗前后分别做全血计数和痰培养。评价标准:①痰量减少,脓性减轻;②体温恢复正常;③胸部X线检查清晰。3项标准均达到为良好;只达到头2项标准,于开始治疗的14天内X线检查肺部未能清晰为中等;上述3项均未达到,治疗开始的1周内,需要改变抗菌素的列为无效。结果复方磺胺增效剂治疗组中有43例(68.2%)疗效良好,而四环素组病人中只有23例(36.5%)(P<0.01)。接受复方磺胺增效剂治疗的63例中只有3例无效,其中1例是严重的克雷白氏杆菌感染,1例属绿脓杆菌感染,而另1例为混合感染。四环素治疗组中14例无效,其中9例混合感染,2例流感杆菌感染,
A total of 126 patients with acute lower respiratory tract infection with systemic manifestations were randomly divided into two groups. Group A received 480 mg of sulfonamide synergist and 2,400 mg of sulfamethoxazole (3 tablets every 12 hours) daily while Group B consumed 500 mg of tetracycline hydrochloride every 6 hours. Before and after treatment were done whole blood count and sputum culture. Evaluation criteria: ① reduce the amount of sputum, purulent relief; ② body temperature returned to normal; ③ chest X-ray examination clear. The three criteria were all good; only the first two criteria were met, and the lungs were not clearly defined as X-ray within 14 days of starting treatment; none of the above 3 items were met. The antibiotics need to be changed within 1 week after the start of treatment As invalid. RESULTS: Forty-three patients (68.2%) in the sulfasalazine treatment group had good efficacy compared with 23 (36.5%) patients in the tetracycline group (P <0.01). Only 3 of 63 patients treated with sulfamethoxazole were ineffective, 1 of which was severe Klebsiella pneumoniae infection, 1 was a Pseudomonas aeruginosa infection and 1 was a mixed infection. In the tetracycline group, 14 cases were ineffective, of which 9 were mixed with infection, 2 were infected with influenza bacilli,