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乳腺叶状肿瘤是一种罕见的上皮和间质增生的双相性肿瘤,具有重要的临床意义。尽管c-Kit在乳腺叶状肿瘤间质中的表达已有许多文献报道,但其在上皮中表达的作用尚不清楚。为深入了解c-Kit在乳腺叶状肿瘤间质和上皮中表达的意义,作者对菲律宾大学的一个乳腺叶状肿瘤队列进行分析。该研究共收集2009~2012年不同医疗机构提供的乳腺叶状肿瘤77例,除总结这些病例的临床病理特点外,还采用组织芯片和免疫组化对c-Kit的表达特点进行分析。
Breast leaf tumor is a rare epithelial and interstitial hyperplasia of biphasic tumors, has important clinical significance. Although the expression of c-Kit in the interstitial of breast phyllodes tumor has been reported in many literatures, the role of c-Kit in epithelial expression remains unclear. To understand the significance of c-Kit expression in mesenchyme and epithelium of breast phyllodes tumor, we analyzed a cohort of breast phyllodes tumors from the University of the Philippines. In this study, we collected 77 cases of breast phyllodes tumor from different medical institutions from 2009 to 2012. In addition to summarizing the clinicopathological features of these cases, the expression characteristics of c-Kit were also analyzed by tissue microarray and immunohistochemistry.