论文部分内容阅读
Objective: To investigate the expressions of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (Ki-67) in patients with rectal adenocarcinoma and their associations with neoadjuvant therapy. Methods: The expressions of Ki-67 and VEGF in 32 cases of rectal adenocarcinoma, including both pretreatment tumor biopsies and postoperative specimen, were detected by immunohistochemistry using specific antibodies, and were correlated with clinico- pathological factors. Results: The intensity of VEGF staining was significantly correlated with lymph nodal metastasis (P = 0.033), depth of tumor invasion (P = 0.007) and tumor stage (P = 0.016), but not with histological types, tumor sizes, patients’ ages and genders (P > 0.05). Low level of VEGF expression had significant correlation with the high sensitivity of response to neoadjuvant therapy (P = 0.016). The transient increase of VEGF expression could be seen after neoadjuvant therapy (P = 0.035). Ki-67 labeling index (Ki-67-LI) was significantly correlated with lymph node metastasis (P = 0.028), but not correlated to tumor sizes, patients’ ages and genders (P > 0.05). Tumors with lower Ki-67-LI were more sensitive to neoadjuvant therapy (P = 0.032). The Ki-67 level decreased after neoadjuvant therapy, but no statistical significance was found (P > 0.05). Conclu- sion: Our results demonstrate that the expression of VEGF and Ki-67 in pretreatment rectal adenocarcinoma biopsies may be predictive of tumor response to neoadjuvant therapy.
Objective: To investigate the expressions of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (Ki-67) in patients with rectal adenocarcinoma and their associations with neoadjuvant therapy. Methods: The expressions of Ki-67 and VEGF in 32 cases of rectal adenocarcinoma, including both pretreatment tumor biopsies and postoperative specimens, were detected by immunohistochemistry using specific antibodies, and were correlated with clinico-pathological factors. Results: The intensity of VEGF staining was significantly correlated with lymph nodal metastasis (P = 0.033), depth (P = 0.016), but not with histological types, tumor sizes, patients ages and genders (P> 0.05). Low level of VEGF expression had significant correlation with the high sensitivity of response to neoadjuvant therapy (P = 0.016). The transient increase of VEGF expression could be seen after neoadjuvant therapy (P = 0.035). Ki-67 labeling Tumors with lower Ki-67-LI were more correlated with lymph node metastasis (P = 0.028), but not correlated with tumor sizes, patients ages and genders (P> 0.05) The Ki-67 level decreased after neoadjuvant therapy, but no statistical significance was found (P> 0.05). Concluses: Our results demonstrate that the expression of VEGF and Ki-67 in pretreatment rectal adenocarcinoma biopsies may be predictive of tumor response to neoadjuvant therapy.