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目的:研究急性心肌梗塞(AMI)后使用他汀类降脂药物对病人死亡率的影响,及其与血脂水平的关系。方法:对1994年1月至2004年6月期间254例AMI病人(他汀类药物治疗组,简称他汀组156例,未用他汀组98 例)进行随访(平均随访421 d)以确定转归。回顾性分析AMI病人住院时他汀类药物等治疗情况和血脂水平,进行Cox多因素生存分析,研究他汀类药物与AMI死亡率的关系。结果:他汀类药物使用与AMI死亡率独立相关(OR =0.24,95%CI=0.12-0.46,P<0.001)。他汀组死亡23例(14.7%),无他汀组死亡27例(27.6%),两组之间有显著差异(P<0.05),他汀组中高脂血症者与血脂水平正常者死亡率无显著差异(P>0.05)。结论:AMI后使用他汀类药物能减少AMI死亡率,且与血脂水平无关。
Objective: To study the effect of statin lipid-lowering drugs on patient mortality after acute myocardial infarction (AMI) and its relationship with serum lipid levels. Methods: A total of 254 AMI patients (statin-treated group, 156 statin-treated patients and 98 non-statin-treated patients) were followed up for an average of 421 days from January 1994 to June 2004 to determine the outcome. Retrospective analysis of AMI patients hospitalized statins and other blood lipids levels, Cox multivariate survival analysis to study statins and AMI mortality. Results: Statin use was independently associated with AMI mortality (OR = 0.24, 95% CI = 0.12-0.46, P <0.001). There were 23 deaths (14.7%) in the statin group and 27 (27.6%) in the non-statin group, with significant difference between the two groups (P <0.05). There was no significant mortality in the statin group with hyperlipidemia and normal blood lipids Difference (P> 0.05). Conclusions: The use of statins after AMI reduces AMI mortality and is independent of lipid levels.