J.Am.Chem.Soc.2014,136,17426~17429链状手性脂肪醇结构广泛存在于天然产物分子中,也是许多手性药物的重要结构组成部分.尽管化学家们在过去几十年中已经发展了许多不对称合成方法,但手性脂肪醇的高效、高选择性合成仍然是一个挑战.例如,羰基化合物的不对称催化氢化反应目前仅适用于具有大位阻烷基的手性脂肪醇的合成.因此,从消旋的手性脂肪醇进行动力学拆分仍然是获取光学活性手性脂肪醇的主要方法.然而,在目前已报道的消旋手性脂肪醇的动力学拆分中,一个对映异构体的羟基被转变成其它官能团,因而损失了一半的底物.最近,南开大学元素有机化学研究所周其林、谢建 J. Am. Chem. Soc. 2014, 136, 17426-17429 Chiral chiral fatty alcohol structures are found extensively in natural product molecules and are also an important structural component of many chiral drugs. Although chemists in the past few decades Many asymmetric synthesis methods have been developed but the efficient and highly selective synthesis of chiral fatty alcohols remains a challenge. For example, the asymmetric catalytic hydrogenation of carbonyl compounds is currently only applicable to chiral compounds with sterically hindered alkyl groups Therefore, the kinetic resolution of racemic chiral fatty alcohols is still the main method for obtaining optically active chiral fatty alcohols.However, the kinetic resolution of racemic chiral fatty alcohols reported so far Points, one enantiomer of the hydroxyl group is converted into other functional groups, thus losing half of the substrate.Recently, Nankai University Institute of Elemental Organic Chemistry Zhou Qilin, Xie Jian