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微核率(MN)已成功地用作定量鉴定不同化学物质对造血细胞的诱变或辐射防护效应以及经X线治疗的人淋巴细胞染色体畸变的指标。微核测定法是基于染色体断裂和微核形成之同存在着直接相关而建立起来的。受照后形成的微核代表了从细胞染色体组丢失的遗传物质。所以,具有微核的细胞可以看作是细胞增
The micronucleus rate (MN) has been successfully used as an index to quantitatively identify mutagenic or radioprotective effects of different chemicals on hematopoietic cells as well as X-ray treatment of human lymphocyte chromosome aberrations. Micronuclear assay is based on the direct correlation between the existence of chromosome rupture and micronucleus formation. Micronuclei formed upon irradiation represent genetic material lost from the cell’s chromosomal set. Therefore, the cells with micronuclei can be considered as cell proliferation