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[目的]分析2011年静安区疑似预防接种后不良反应(Adverse Event Following Immunization,AEFI)数据,为提高监测工作质量,维护预防接种安全性提供依据。[方法]在常规监测的基础上,2011年7～9月对5家预防接种门诊接种对象开展主动监测,记录AEFI发生时间、疫苗接种时间、疫苗种类、报告时间、临床表现等信息,并分析比较。[结果]2011年静安区报告AEFI共249例次,平均报告率为289.49次/10万剂次,以一般反应为主。主动监测报告率为910.84次/10万剂次,常规监测报告率为84.99次/10万剂次,主动监测报告率为常规监测报告率的10.7倍。常规监测与主动监测中,AEFI报告率较高的疫苗较近似,但并不完全一致。[结论]静安区常规AEFI监测有效开展,但监测敏感度和监测质量尚存在进一步提高的空间,影响监测敏感性和监测质量的因素尚有待于进一步探讨。
[Objective] To analyze the data of suspected adverse reaction after immunization (AEFI) in 2011 in Jing’an District to provide the basis for improving the quality of monitoring work and maintaining the safety of vaccination. [Methods] On the basis of routine monitoring, from July to September in 2011, five outpatients in vaccination clinic were monitored actively and the information such as time of onset of AEFI, time of vaccination, type of vaccine, report time and clinical manifestation were recorded and analyzed Compare [Results] AEFI in Jing’an District reported a total of 249 cases in 2011 with the average reported rate of 289.49 times / 100 000 doses, with the general reaction as the main factor. Active monitoring report rate of 910.84 times / 100 000 doses, routine monitoring report rate of 84.99 times / 100 000 doses, active monitoring report rate of 10.7 times the regular monitoring report rate. In conventional and active surveillance, vaccines with higher AEFI reporting rates are more approximate, but not entirely consistent. [Conclusion] The routine AEFI monitoring in Jing’an District has been carried out effectively, but there is room for further improvement in monitoring sensitivity and monitoring quality. The factors that affect the monitoring sensitivity and monitoring quality need to be further explored.