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目的观察累积高血压暴露与颈动脉斑块检出率的关系。方法采用回顾性研究的方法,以连续参加2006-2007、2008-2009、2010-2011、2012-2013年开滦集团公司4次体检且资料完整的5440名职工作为研究人群。按照4次体检检出高血压的频度将人群分为高血压暴露0、2、4、6、8年组,采用多因素Logistic回归方法,分析累积高血压暴露与颈动脉斑块检出率的关系。结果资料完整的观察对象为3764名[男性2076名(55.2%),女性1688名(44.8%)],年龄(55.8±10.1)岁。随着累积高血压暴露时间的增加,颈动脉斑块检出率呈现逐步增高的趋势,从暴露0年组到暴露8年组的颈动脉斑块检出率分别为31.5%、43.9%、50.2%、54.1%和63.9%(P趋势<0.05)。多因素Logistic回归分析结果显示,校正其他混杂因素后,与高血压暴露0年组相比,高血压暴露2年组、4年组、6年组、8年组颈动脉斑块检出率的风险增加(分别OR=1.52、1.83、1.64、2.19)。结论累积高血压暴露是颈动脉斑块检出率的独立危险因素。
Objective To observe the relationship between cumulative hypertension and carotid plaque detection. Methods A retrospective study was conducted in a series of 5440 workers who participated in the four physical examinations of Kailuan Group in 2006-2007, 2008-2009, 2010-2011, 2012-2013 consecutively. According to the frequency of 4 times of examination of hypertension, the population was divided into groups of hypertension exposed for 0, 2, 4, 6 and 8 years. Multivariate logistic regression was used to analyze the relationship between cumulative hypertension and carotid plaque detection Relationship. Results A total of 3764 subjects (2076 males (55.2%) and 1688 females (44.8%)] were included in the data set, with a mean age of 55.8 ± 10.1 years. The detection rate of carotid plaques showed a gradual increase with the increase of exposure time to cumulative hypertension. The detection rates of carotid plaques from the 0-year exposure group to the 8-year exposure group were 31.5%, 43.9% and 50.2 %, 54.1% and 63.9% respectively (P trend <0.05). Multivariate logistic regression analysis showed that after correcting for other confounding factors, the detection rate of carotid plaques in hypertensive group 2, 4, 6 and 8 years was significantly higher than that in 0-year hypertension group Risks increased (OR = 1.52, 1.83, 1.64, 2.19, respectively). Conclusion Cumulative hypertension is an independent risk factor for carotid plaque detection.