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临床流行病学研究显示,血压与心血管病风险间存在线性关系,血压>115/70 mm Hg(1 mm Hg=0.133kPa)时,心血管病风险随着血压水平上升而进一步增加。与此同时,既往数十年间开展的大量随机对照临床试验(randomized controlled trial,RCT)一致地显示,降低血压可以显著减少血管事件的发生,包括死亡。因而国内外众多高血压指南一致认可“降压是降低(血管)事件的基础”~([1-3])。然而,对于这一论断,仍需辩证看待。
Clinical epidemiological studies have shown a linear relationship between blood pressure and the risk of cardiovascular disease, with a further increase in the risk of cardiovascular disease as blood pressure levels rise above 115/70 mm Hg (1 mm Hg = 0.133 kPa). In the meantime, a large number of randomized controlled trials (RCTs) conducted over decades have consistently shown that lowering blood pressure significantly reduces the incidence of vascular events, including death. Therefore, many domestic and foreign guidelines for hypertension unanimously approved that “blood pressure reduction is the basis for reducing (vascular) events” ~ ([1-3]). However, this argument still needs to be viewed dialectically.