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目的了解海南省汉族人群中乙型肝炎病毒(HBV)基因型与肝功能之间的关系。方法采用实时荧光聚合酶链反应(RT-PCR)法对海南省83例HBV阳性而且未进行抗病毒治疗的汉族慢性乙型肝炎患者的血清进行检测和HBV基因分型。结果在83例患者中,B型38例(占45.78%),C型34例(占40.96%),D型7例(占8.44%),基因型B+C混合感染4例(占4.82%),未发现其它基因型。受检者中,基因型C型的患者血清ALT(219.32±58.24U/L)、TBIL(57.74±24.87μmol/L)水平较B型增高(P<0.01)。结论海南地区汉族人群中HBV基因型主要为B型和C型;存在D型及B、C混合感染。C型HBV的感染可能引起更严重的肝脏损害。
Objective To understand the relationship between hepatitis B virus (HBV) genotypes and liver function in Han Chinese in Hainan Province. Methods The real-time fluorescence polymerase chain reaction (RT-PCR) method was used to detect the sera of 83 patients with HBV-positive and non-antiviral treatment in Han nationality with chronic hepatitis B in Hainan Province. Results Among the 83 patients, 38 were type B (45.78%), 34 were type C (40.96%), 7 were type D (8.44%), 4 were genotype B + C (4.82% ), No other genotypes were found. The level of serum ALT (219.32 ± 58.24U / L) and TBIL (57.74 ± 24.87μmol / L) in patients with genotype C was significantly higher than that of patients with genotype C (P <0.01). Conclusion The HBV genotypes in Han population in Hainan are mainly B and C genotypes. There are D and B and C mixed infections. Infection with type C HBV may cause more severe liver damage.