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本文回顾性地研究了58例具有18三体妊娠的母亲血清及羊水中的α-胎甲球蛋白。除 Down’s 综合征外,18三体是最常见的常染色体三体疾患,活产率为0.16～0.3/1000分娩。诊断常染色体三体,常经腹壁羊膜穿刺术,该病在妊娠晚期死亡率是很高的,在16周时50～90%的胎儿存活,但不能生存至活产,晚期胎儿发育迟缓,也有很多未被诊断的病例早产和做剖腹产,存活很少,头1个月死亡82%,1年后仅1/49存活。与21三体比较,在宫内和分娩后存活是短得多,且不健康。
This article retrospectively studied 58 mothers with 18 trisomy 18 pregnancies and amniotic fluid amniotic fetoprotein. In addition to Down’s syndrome, trisomy 18 is the most common autosomal trisomy and has a live birth rate of 0.16 to 0.3 per 1,000 deliveries. Diagnosis of autosomal trisomy, often by abdominal amniocentesis, the disease in late pregnancy mortality is very high at 16 weeks, 50 to 90% of the fetus to survive, but can not survive to live births, late fetal growth retardation, there are Many of the undiagnosed cases are premature and caesarean, with few survivals, 82% of deaths in the first month and only 1 / 49th of a year later. Compared with the trisomy 21, survival in the uterus and after childbirth is much shorter and unhealthy.