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目的探讨慢性脑供血不足(CCCI)与血浆中特定的磷脂(AP)的相关性,以评价AP是否可以作为诊断CCCI的标准之一。方法选择CCCI患者1212例为CCCI组,同期选择无CCCI症状者202例为对照组,用比色法测定AP。采用ROC曲线下面积等评估测定AP的准确性。结果与对照组比较,CCCI组血浆AP水平显著升高[(6.27±0.69)Uυs(4.37±0.79)U,P<0.01]。CCCI组血浆AP水平与年龄无相关性(r=0.001,P=0.902)。用血浆AP作为CCCI的诊断方法的准确性较高,其ROC曲线下面积为0.961(95%CI:0.946~0.976,P<0.01)。AP正常界值=5.39 U时,敏感性为92.1%,特异性为89.1%。结论 CCCI患者具有血浆AP水平升高的生化特性。AP可能是诊断CCCI的一个较好的分子标记物。
Objective To investigate the correlation between chronic cerebral hypoperfusion (CCCI) and specific phospholipids (AP) in plasma to evaluate whether AP can be used as one of the criteria for the diagnosis of CCCI. METHODS: A total of 1212 CCCI patients were selected as the CCCI group. 202 non-CCCI patients were selected as the control group during the same period. AP was measured by colorimetry. The area under the ROC curve was used to assess the accuracy of the AP. Results Compared with the control group, the level of plasma AP in CCCI group was significantly increased [(6.27 ± 0.69) Uvs (4.37 ± 0.79) U, P <0.01]. There was no correlation between plasma AP levels and CCCI age (r = 0.001, P = 0.902). The diagnostic accuracy of plasma AP for CCCI was high, with an area under the ROC curve of 0.961 (95% CI: 0.946-0.976, P <0.01). When the normal value of AP was 5.39 U, the sensitivity was 92.1% and the specificity was 89.1%. Conclusion CCCI patients with elevated plasma AP levels of biochemical characteristics. AP may be a better molecular marker for the diagnosis of CCCI.