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目的探讨早期继续出血的自发性脑出血患者氧化应激及炎性介质水平的变化。方法选取脑出血继续出血患者(观察组)与非继续出血患者(稳定组)、健康对照组(对照组)各48例,分别检测各组不同时间点的丙二醛(MDA)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)和IL-6的水平变化。结果各时间点观察组、稳定组的MDA、SOD、TNF-α和IL-6水平均明显高于对照组,(P<0.01);与稳定组比较,观察组各时间点的MDA、SOD、TNF-α和IL-6水平显著升高(P<0.05),且在出血早期(24~48 h)氧化应激及炎性反应最为显著(P<0.05)。结论氧化应激及炎性反应可能共同参与了自发性脑出血早期继续出血的发生及发展,可能是继续出血的机制之一。
Objective To investigate the changes of oxidative stress and inflammatory mediators in spontaneous intracerebral hemorrhage patients with early hemorrhage. Methods 48 patients with continuous hemorrhage (observation group) and non-continuous hemorrhage (stable group) and 48 healthy control group (control group) were selected to detect the levels of malondialdehyde (MDA), superoxide (SOD), tumor necrosis factor-α (TNF-α) and IL-6 levels. Results Compared with the control group, the levels of MDA, SOD, TNF-α and IL-6 in the observation group and the control group at each time point were significantly higher than those in the control group (P <0.01) The levels of TNF-α and IL-6 were significantly increased (P <0.05), and the oxidative stress and inflammatory reaction were the most significant at the early stage of hemorrhage (24-48 h) (P <0.05). Conclusions Oxidative stress and inflammatory reaction may participate in the occurrence and development of continuous hemorrhage in early stage of spontaneous intracerebral hemorrhage and may be one of the mechanisms of continued bleeding.