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目的:探析奥美拉唑与阿奇霉素及左氧氟沙星治疗幽门螺杆菌相关性消化性溃疡的临床效果。方法:选择2014年10月至2016年2月广州市增城区永宁街永和社区卫生服务中心收治的96例幽门螺杆菌相关性消化性溃疡患者,根据随机数字法分为两组,其中给予对照组甲硝唑+阿莫西林+雷贝拉唑三联法治疗,而观察组则运用左氧氟沙星+阿奇霉素+奥美拉唑三联法治疗,比较两组患者治疗效果。结果:相比较对照组而言,观察组的治疗有效率高,组间比较,差异具有统计学意义(P<0.05);与对照组比较,观察组的幽门螺杆菌转阴率较高,组间对比,差异具有统计学意义(P<0.05);同时,两组不良反应发生率比较,差异具有统计学意义(P<0.05)。结论:临床上给予幽门螺杆菌相关性消化性溃疡患者阿奇霉素+奥美拉唑+左氧氟沙星治疗,不仅疗效显著,还不容易发生不良反应,具有较高的用药安全性。
Objective: To investigate the clinical efficacy of omeprazole with azithromycin and levofloxacin in the treatment of Helicobacter pylori-associated peptic ulcer. Methods: From October 2014 to February 2016, 96 patients with H. pylori-associated peptic ulcer were enrolled in Yonghe Community Health Service Center, Yongning Street, Zengcheng District, Guangzhou. Patients were divided into two groups according to random number method, and the control group Metronidazole + amoxicillin + rabeprazole triple therapy, while the observation group was treated with levofloxacin + azomycin + omeprazole triple therapy, the treatment effect was compared between the two groups. Results: Compared with the control group, the observation group had a high effective rate of treatment and the difference between the two groups was statistically significant (P <0.05). Compared with the control group, the negative rate of Helicobacter pylori in the observation group was higher, The difference was statistically significant (P <0.05). Meanwhile, there was significant difference between the two groups in the incidence of adverse reactions (P <0.05). Conclusion: Azithromycin + omeprazole + levofloxacin treatment in patients with H. pylori-associated peptic ulcer is not only effective, but also not prone to adverse reactions, and has high safety of medication.