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真核生物的天然免疫是抵抗外界病原体入侵的第一道防线。天然免疫主要是通过模式识别受体来识别病毒或细菌等外来病原体。Nod样受体(NLR)是近年来研究发现的识别胞内菌的模式受体。NLRC5作为Nod样受体家族中最大的一个成员,其生理学功能一直不清楚。4月10号,《细胞研究》(Cell Research)杂志在线发表中科院上海生命科学研究院/上海交通大学医学院健康科学研究所钱友存研究组关于NLRC5在抗胞内菌感染过程中的作用研究(NLRC5 regulates MHC classⅠantigen presentation in host defense
Natural immunity of eukaryotes is the first line of defense against invasion by outside pathogens. Natural immunity is mainly through pattern recognition receptors to identify foreign pathogens such as viruses or bacteria. Nod-like receptors (NLRs) are pattern receptors that have been found in recent years to recognize intracellular bacteria. As one of the largest members of the Nod-like receptor family, NLRC5 has no clear physiological function. On April 10, Cell Research published an online research report on the role of NLRC5 in anti-intracellular bacteria infection by Qian You-cun, Shanghai Institutes for Biological Sciences, Shanghai Institutes for Health Sciences, Shanghai Jiaotong University School of Medicine. (NLRC5 regulates MHC class Iantigen presentation in host defense