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目的 研究中药土贝母皂甙微囊作为血管栓塞剂的有效性、安全性及相关特性。方法以中药土贝母皂甙为囊心 ,乙基纤维素为囊材制成微囊。用 30只新西兰兔行肾动脉栓塞实验。结果土贝母皂甙微囊为白色光滑的圆球形微粒 ,直径 40～ 180 μm ,载药量为 36 % (W/W) ;在 40 %泛影葡胺溶液中悬浮分散性最好 ,经 3F导管注射无堵管现象 ;在 37℃生理盐水中约 2 0d左右微囊全部破裂 ;栓塞后 30d栓侧肾重量和体积均比对侧明显小 (tw=10 2 1,tv=38 0 ,P <0 0 0 1) ,主要栓塞在直径110～ 35 0 μm叶间和弓形动脉 ,术后 30d未见肾动脉再通及侧支循环形成。 结论 土贝母微囊具有良好的血管栓塞作用和缓释特性 ,使用方便、安全 ,是一种较理想的末梢型血管栓塞剂。
Objective To study the efficacy, safety and related characteristics of Chinese medicine Fritillaria saponin microcapsules as vascular embolization agents. The method was based on the use of Chinese medicine Fritillaria saponin as the core and ethyl cellulose as the capsule material to make microcapsules. Renal artery embolization was performed in 30 New Zealand rabbits. Results Fritillaria saponin microcapsules were white smooth round spherical particles with a diameter of 40-180 μm and a drug loading of 36% (W/W). The suspension dispersion was best in 30% diatrizoate solution. Catheter injection did not block the tube; about 37 days, the microcapsules ruptured in physiological saline at about 20 days; the weight and volume of the thrombus side of the embolus were significantly smaller than the contralateral side at 30 days after embolization (tw=102, tv=380). <0 0 0 1), mainly embolized between the diameter of 110 ~ 35 0 m leaf and arcuate artery, no recanalization of the renal artery and collateral circulation formation at 30 days after surgery. Conclusion The Fritillaria microcapsule has good vascular embolism and sustained-release characteristics. It is convenient and safe to use. It is an ideal peripheral vascular embolization agent.