论文部分内容阅读
目的 探讨缺血性脑梗死早期和慢性期 pH值、磷脂及其能量代谢物的变化特征。 方法 脑梗死早期 6例 (发病时间 2～ 14d) ,脑梗死慢性期 6例 (发病后 2～ 6月 ) ,正常组 6例 ,年龄匹配。利用ISIS定域技术采集3 1PMRS资料 ,用jMRUI(1.3)软件进行数据分析 ,计算体素内的 pH值 ,各代谢物与 β ATP的相对比值。结果 正常组pH值 7.0 1～ 7.0 8,平均 7.0 4。脑梗死早期pH值 6 .1～ 6 .90 ,平均 6 .4 5 ,呈碱中毒 ;病灶区Pi增加明显 ,β ATP/Pi与正常组比较有显著性差异 (P =0 .0 0 8<0 .0 5 ) ;PCr减少 ,PCr/β ATP有显著性差异 (P =0 .0 34<0 .0 5 ) ;PME、PDE及ATP减少 ,但小于Pi和PCr变化 ;其中 1例大面积脑梗死 10d后病灶区只检测到高尖Pi峰 ,其它共振峰消失。脑梗死慢性期pH值 7.0 7～ 7.16 ,平均 7.10 ,呈碱中毒 ;PCr、Pi变化不显著性 ;PME、PDE及ATP降低 ;PME/β ATP和PDE/β ATP与正常组比较有显著性差异 (P <0 .0 5 )。结论 脑梗死不同时相pH值、能量及其磷脂代谢物呈现特征性的变化 ,3 1PMRS能为优化脑梗死个性化的治疗方案提供独特的生化信息。
Objective To investigate the changes of pH, phospholipids and their energy metabolites in early and chronic ischemic cerebral infarction. Methods Six cases of early cerebral infarction (onset time 2 ~ 14d), 6 cases of chronic cerebral infarction (2 months after onset), 6 cases of normal group, age-matched. The 3 1 PMRS data were collected by ISIS localization technique and analyzed by jMRUI (1.3) software to calculate the pH value in the voxel and the relative ratio of each metabolite to β ATP. Results The normal group had a pH 7.01 ~ 7.08 with an average of 7.04. In the early stage of cerebral infarction, the pH values ranged from 6.1 to 6.90, with an average of 6.55, showing alkalosis. Pi in the lesion area increased significantly, and there was a significant difference between β ATP / Pi and the normal group (P = 0.080 < (P = 0.304 <0.05); PME, PDE and ATP decreased, but less than the changes of Pi and PCr; 1 case of large area 10d after cerebral infarction lesions were detected only high peak Pi peak, the other formant disappeared. In the chronic phase of cerebral infarction, the pH was 7.07 ~ 7.16, with an average of 7.10, showing alkalosis; the changes of PCr and Pi were not significant; the levels of PME, PDE and ATP were decreased; PME / β ATP and PDE / (P <0. 05). Conclusions The pH, energy and phospholipid metabolites in different phases of cerebral infarction show characteristic changes. 3 1 PMRS can provide unique biochemical information for optimizing personalized treatment of cerebral infarction.