论文部分内容阅读
目的探讨CYP2B6基因多态性与抗结核药物性肝损伤(ADIH)的关系。方法选取在2013年1月至2013年12月唐山市结核病医院确诊并接受规范抗结核治疗的结核病患者中发生肝损伤的175例结核病患者为病例组,未发生肝损伤的185例患者为对照组,对其进行流行病学调查,同时提取外周血DNA并鉴定CYP2B6-785A/G位点的基因型,最后对实验结果进行统计学分析以判断其与ADIH的关系。结果 CYP2B6-785A/G位点多态性AA、AG、GG基因型在病例组(33.1%、52.6%、14.3%)和对照组(35.7%、50.8%、13.5%)中的分布比较,差异无统计学意义(P>0.05),等位基因A、G在病例组和对照组中分别占59.4%、40.6%和61.1%、38.9%,差异无统计学意义(P>0.05)。结论CYP2B6-785A/G位点基因多态性可能与抗结核药物性肝损伤的发生无相关性。
Objective To investigate the relationship between CYP2B6 gene polymorphism and anti-TB drug-induced liver injury (ADIH). Methods One hundred and seventy-five TB patients with liver injury who were diagnosed as having liver injury in Tangshan TB Hospital from January 2013 to December 2013 were selected as case group and 185 patients without liver injury as control group , The epidemiological investigation was carried out, at the same time, the peripheral blood DNA was extracted and the genotype of CYP2B6-785A / G was identified. Finally, the experimental results were statistically analyzed to determine its relationship with ADIH. Results The distribution of genotypes AA, AG and GG of CYP2B6-785A / G polymorphism in case group (33.1%, 52.6%, 14.3%) and control group (35.7%, 50.8%, 13.5% There was no significant difference between the two groups (P> 0.05). The allele A and G accounted for 59.4%, 40.6% and 61.1%, 38.9% of cases and controls, respectively. There was no significant difference (P> 0.05). Conclusion CYP2B6-785A / G polymorphism may be related to the occurrence of anti-TB drug-induced liver injury.