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目的本文根据Ki-67在垂体瘤中的表达,采用统计学工具,研究其在预后评价中的作用。方法根据影像资料获得垂体瘤的大小数据,依据每张切片上的阳性细胞表达百分数计算出Ki-67标记指数。分析复发组和未复发组间的Ki-67标记指数均值的差异,比较临床变量间的Ki-67标记指数的均值,探寻Ki-67标记指数和临床变量间的相关性。分析中采用了Mann-Whitney U检验和Fisher精确检验方法,以及受试者工作特征曲线等分析方法。所有统计计算及分析均在SPSS20.0统计软件上完成。结果 Ki-67标记指数与垂体瘤复发和侵袭性有关系。Ki-67标记指数阈值为3.45%,超过该阈值容易导致垂体瘤术后复发。结论 Ki-67标记指数的增高容易导致垂体瘤术后复发,降低预后效果。Ki-67标记指数对评价垂体瘤的手术预后是一项客观而准确的指标,对临床有一定的指导价值。
Objective According to the expression of Ki-67 in pituitary adenomas, we use statistical tools to study its role in prognosis evaluation. Methods The size of pituitary tumor was obtained according to the image data. Ki-67 labeling index was calculated based on the percentage of positive cells expressed on each slice. The difference of mean Ki-67 index between recurrence group and non-recurrence group was analyzed. The mean value of Ki-67 index between clinical variables was compared to explore the correlation between Ki-67 index and clinical variables. Mann-Whitney U test and Fisher’s exact test were used in the analysis, as well as analysis methods such as receiver operating characteristic curve. All statistical calculations and analysis are done on SPSS 20.0 statistical software. Results The Ki-67 labeling index was related to recurrence and invasiveness of pituitary tumor. Ki-67 labeling index threshold was 3.45%, beyond which the threshold of pituitary tumor easily lead to recurrence. Conclusion Increased Ki-67 labeling index easily lead to recurrence of pituitary tumor and reduce the prognosis. The Ki-67 labeling index is an objective and accurate indicator for the evaluation of the prognosis of pituitary adenoma, and has certain guiding value in clinical practice.