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目的:探讨消斑Ⅰ号对外阴营养不良患者P21蛋白表达的调控作用。方法:取30例外阴营养不良患者皮损表皮细胞和10例正常人表皮细胞,采用免疫组织化学方法检测其中P21蛋白的表达情况,并与消斑Ⅰ号治疗后P21蛋白在各型外阴营养不良中的表达进行比较。结果:各型外阴营养不良患者治疗前P21蛋白表达高于正常组,差异有显著性(P<0.05)。经治疗后,增生组、萎缩组、混合组P21表达降低,与治疗前比有显著性差异(P<0.05)。结论:消斑Ⅰ号能显著改善临床症状,并通过降低皮损表皮细胞P21的阳性表达率达到治疗作用。
Objective: To investigate the regulatory effect of Xiaoban Ⅰ on P21 protein expression in patients with vulvar dystrophy. Methods: 30 cases of epidermal cells of vulvar dystrophy and 10 cases of normal human epidermal cells were collected. The expression of P21 protein was detected by immunohistochemical method. In the expression of comparison. Results: The expression of P21 protein in patients with various types of vulvar dystrophy before treatment was significantly higher than that in the normal group (P <0.05). After treatment, the expression of P21 in proliferative group, atrophic group and mixed group decreased, which was significantly different from that before treatment (P <0.05). Conclusion: Xiaoban Ⅰ can significantly improve the clinical symptoms, and by reducing the expression of P21 in the lesional epidermal cells to achieve the therapeutic effect.