论文部分内容阅读
目的比较由不同材料生产的膜型血浆分离器PS-06和Evacure-4A在人工肝血浆置换治疗中,患者血生化及凝血功能的变化。方法 1999～2010年,于我院行人工肝血浆置换治疗的肝衰竭患者240例中,2002年前采用PS-06血浆分离器120例,2003年起采用Evacure-4A血浆分离器120例。两组患者均以内科综合治疗为基础,联合人工肝血浆置换治疗。检测人工肝血浆置换治疗前后血液生化指标及凝血功能。结果两种膜型血浆分离器在降低TBil、AST,改善凝血功能方面的差异无统计学意义(P>0.05);在提高ALB、降低ALT水平的差异有统计学意义(P<0.05)。结论应用Evacure-4A膜型血浆分离器可明显提高ALB和降低ALT水平。
Objective To compare the changes of blood biochemistry and coagulation in patients undergoing artificial hepatic plasma exchange with membrane-type plasma separators PS-06 and Evacure-4A made of different materials. Methods From 1999 to 2010, 240 patients with hepatic failure treated with artificial liver plasma exchange in our hospital were enrolled in this study. 120 patients were treated with PS-06 plasma separator before 2002 and 120 patients with Evacure-4A plasma separator since 2003. Two groups of patients were based on comprehensive medical treatment, combined with artificial liver replacement therapy. Blood biochemical parameters and coagulation function were measured before and after artificial liver replacement therapy. Results There was no significant difference between the two membrane type plasma separators in reducing TBil, AST, and improving coagulation function (P> 0.05). There was significant difference in increasing ALB and decreasing ALT (P <0.05). Conclusion Evacure-4A membrane-type plasma separator can significantly improve the ALB and reduce the level of ALT.