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将220名健康的医学生和教工随机分为5组,分别接种2.5μg、5μg、10μg和20μg酵母重组乙型肝炎疫苗或20μg血源疫苗。按0、1、2免疫程序接种后,所有受种者均于第11个月加强接种1剂20μg酵母疫苗。分别于第0、1、2、3、6、11、12、29和36个月采血检测抗体。接种疫苗后,50%的受种者接种部位有轻度或中度疼痛,15%有头痛、头晕症状。20μg酵母疫苗组和血源疫苗组的副作用无显著差别。副作用随接种次数的增加呈下降趋势。
220 healthy medical students and labors were randomly divided into 5 groups and inoculated 2.5μg, 5μg, 10μg and 20μg yeast recombinant hepatitis B vaccine or 20μg blood vaccine respectively. After vaccination with 0,1,2 immunization programs, all recipients were boosted with 1 dose of 20μg yeast vaccine on the 11th month. Blood samples were collected at 0, 1, 2, 3, 6, 11, 12, 29 and 36 months respectively. After vaccination, 50% of recipients have mild or moderate pain at the site of vaccination and 15% have headache and dizziness. There was no significant difference in the side effects between the 20 μg yeast vaccine group and the blood-borne vaccine group. Side effects with the increase in the number of vaccinations showed a downward trend.