目的观察螺旋藻多糖对糖尿病大鼠血糖及胰岛素水平的影响及其作用机制。方法雄性SD大鼠腹腔注射链尿佐菌素制备糖尿病模型,将造模成功大鼠按照血糖值和体重随机分为糖尿病模型组、阳性对照组(格列本脲,20 mg/kg)、螺旋藻多糖高剂量组(200 mg/kg)和低剂量组(100 mg/kg),经口灌胃给药;另设正常对照组。时间为8周,观察螺旋藻多糖对糖尿病大鼠体重、血糖、血清中胰岛素含量、β细胞功能指数和胰腺病理学改变的影响。结果模型组大鼠体重和血糖分别为(219.0±18.6)g、(27.6±2.4)mmol/L,胰岛素含量和β细胞功能指数分别为(7.19±2.55)μU/ml、6.62±2.95;螺旋藻多糖高、低剂量组体重和血糖分别为(273.0±26.9)g、(9.2±4.4)mmol/L和(270.1±43.4)g、(15.4±3.7)mmol/L,胰岛素含量和β细胞功能指数分别为(10.45±3.64)μU/ml、(9.34±2.12)μU/ml和95.48±43.27、62.47±53.51。结论螺旋藻多糖可降低血糖,增加血清中胰岛素含量和β细胞功能指数,其作用机制可能是通过修复受损的胰岛细胞,增加β细胞胰岛素的分泌发挥作用。 Objective To observe the effects of Spirulina platensis polysaccharide on blood glucose and insulin levels and its mechanism of action in diabetic rats. Methods Male Sprague-Dawley rats were injected intraperitoneally with streptozotocin to prepare diabetic model. The successful model rats were randomly divided into diabetic model group, positive control group (glibenclamide, 20 mg / kg), spiral Algae polysaccharide high-dose group (200 mg / kg) and low-dose group (100 mg / kg), oral gavage; another normal control group. Time was 8 weeks. Effects of Spirulina platensis polysaccharide on body weight, blood glucose, serum insulin, β-cell function index and pathological changes of pancreas were observed. Results The body weight and blood glucose in the model group were (219.0 ± 18.6) g and (27.6 ± 2.4) mmol / L, respectively. The contents of insulin and β cell index were (7.19 ± 2.55) μU / ml and 6.62 ± 2.95, The body weight and blood glucose of high and low dose polysaccharides group were (273.0 ± 26.9) g, (9.2 ± 4.4) mmol / L and (270.1 ± 43.4) g, (15.4 ± 3.7) mmol / L respectively. Insulin content and β cell function index (10.45 ± 3.64) μU / ml, (9.34 ± 2.12) μU / ml and 95.48 ± 43.27, 62.47 ± 53.51, respectively. Conclusion Spirulina platensis polysaccharide can reduce blood glucose, increase serum insulin content and β-cell function index, the mechanism may be through repair of damaged islet cells, increasing β-cell insulin secretion play a role.