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Purpose: This study was performed to assess the corneal penetration of three topically applied fluoroquinolones (levo-floxacin, norfloxacin and lomefloxacin) in corneal buttons obtained from patients undergoing penetrating keratoplasty. Methods: Fourteen patients received three drops each of 0.5% levofloxacin, 0.3% norfloxacin and 0.3% lomefloxacin (the standard clinically available preparations) over a 30- min interval beginning 90 mins before their scheduled keratoplasty. Corneal samples obtained from excised buttons at the time of surgery were stored at - 80° until analysis. The concentration of the administeredfluoroquinolones was measured using high-performance liquid chromatography. Results: The mean corneal concentration of levofloxacin (4.6± 3.5 μ g/g, mean± standard deviation) was significantly higher than that of lomefloxacin (2.7± 1.8 μ g/g, p=0.0018) and norfloxacin (1.3 ± 1.2 μ g/g, p=0.00012). Conclusion: Levofloxacin achieves a higher mean corneal concentration than norfloxacin and lomefloxacin in the human cornea.
Methods: This study was performed to assess the corneal penetration of three topically applied fluoroquinolones (levo-floxacin, norfloxacin and lomefloxacin) in corneal buttons obtained from patients undergoing penetrating keratoplasty. Methods: Fourteen patients received three drops each of 0.5% levofloxacin, 0.3% norfloxacin and 0.3% lomefloxacin (the standard clinically available preparations) over a 30- min interval beginning 90 mins before their scheduled keratoplasty. Corneal samples obtained from excised buttons at the time of surgery were stored at - 80 ° until analysis. The concentration of the Results: The mean corneal concentration of levofloxacin (4.6 ± 3.5 μg / g, mean ± standard deviation) was significantly higher than that of lomefloxacin (2.7 ± 1.8 μg / g, p = 0.0018) and norfloxacin (1.3 ± 1.2 μg / g, p = 0.00012). Conclusion: Levofloxacin achieves a higher mean corneal concentration t han norfloxacin and lomefloxacin in the human cornea.