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目的总结目前长链非编码RNA(long noncoding RNA,lnc RNA)在胃癌转移中的作用及研究进展。方法通过Web of Knowledge、Pubmed等数据库检索并下载有关lnc RNAs和胃癌转移相关文献,对lnc RNAs参与胃癌转移相关文献进行分析。结果近年来lnc RNAs作为研究热点,越来越受到研究者的重视,它们能够在染色质、转录和转录后水平参与基因调节。lnc RNAs在胃癌中异常表达,并通过调节胃癌血管生成、细胞间连接和细胞外基质调节胃癌转移。结论 lnc RNAs作为胃癌转移的重要调节因素,可以作为胃癌治疗的分子靶点,为深入研究如何防治胃癌的转移提供了一种有效的科学思路。
Objective To summarize the role of long-length noncoding RNA (lnc RNA) in gastric cancer metastasis and its research progress. Methods The literature about lnc RNAs and gastric cancer metastasis was retrieved and downloaded from databases such as Web of Knowledge and Pubmed, and the related literature about lnc RNAs involved in gastric cancer metastasis was analyzed. Results In recent years, lnc RNAs have attracted more and more researchers’ attention. They are involved in gene regulation at chromatin, transcriptional and post-transcriptional levels. lnc RNAs are abnormally expressed in gastric cancer and regulate gastric cancer metastasis by regulating gastric cancer angiogenesis, cell junctions and extracellular matrix. Conclusion As an important regulator of gastric cancer metastasis, lnc RNAs can be used as a molecular target for the treatment of gastric cancer and provide an effective scientific approach for further research on how to prevent and treat gastric cancer metastasis.