论文部分内容阅读
目的：探讨慢性乙型肝炎血清透明质酸（ＨＡ）水平与肝组织病理变化的关系。方法：采用放射免疫法测定血清ＨＡ水平，并与肝活检组织病理分级分期进行相关分析。结果：慢性肝炎肝组织炎症活动程度越重或肝纤维化程度越明显则血清ＨＡ水平越高（Ｐ＜ ０．０５或０．０１）；血清ＨＡ水平与血清总胆红素（Ｔｂｉｌ）水平呈正相关，与白蛋白（Ａ）、Ａ／Ｇ和凝血酶原活动度（ＰＴＡ）呈负相关，而与血清丙氨酸转氨酶（ＡＬＴ）和γ－球蛋白（γ－Ｇ）则相关不明显（Ｐ＞ ０．０５）。伴有早期肝硬化的慢性肝炎患者其血清ＨＡ水平显著高于不伴有早期肝硬化者（Ｐ＜ ０．０１）。结论：测定血清ＨＡ水平对判断慢性肝炎肝组织的炎症活动程度和纤维化程度有一定的参考价值。
Objective: To investigate the relationship between serum hyaluronic acid (HA) and pathological changes of liver in chronic hepatitis B patients. Methods: Serum HA levels were determined by radioimmunoassay and correlated with pathological grading and staging of liver biopsy. Results: Serum levels of HA were higher in patients with chronic hepatitis (P <0.05 or 0.01), and the levels of serum HA were positively correlated with the levels of total bilirubin (Tbil) , But negatively correlated with albumin (A), A / G and prothrombin activity (PTA), but not with serum alanine aminotransferase (ALT) and γ-globulin P> 0.05). Serum HA levels in patients with chronic hepatitis with early cirrhosis were significantly higher than those without early cirrhosis (P <0.01). Conclusion: The determination of serum HA level has certain reference value for judging the degree of inflammatory activity and the degree of fibrosis in liver tissue of chronic hepatitis.