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目的 寻找接触焦炉逸散物的焦炉工人肺癌的早期监护指标。方法 用Ｄｏｔ ｂｌｏｔ 方法检测５６ 名焦炉作业工人及３２ 名对照组人群血清中ｒａｓ 基因产物ｐ２１ 蛋白和ＨＳＰ２７ 、ＨＳＰ７０ 的水平。结果 焦炉工人血清的ｐ２１ 蛋白明显高于对照组（ Ｐ＜ ０－０１） ，且其阳性率为３５－７ ％ ，显著高于对照组（１２－５ ％ ，Ｐ＜０－０５） ；相关分析表明，焦炉工ｐ２１ 水平与工人工龄存在极显著相关（ Ｐ＜ ０－００１） 。同时焦炉工人血清ＨＳＰ２７水平也明显高于对照组（ Ｐ＜ ０－０５） ，ＨＳＰ７０ 水平两组间无显著差异。结论 推测血清中ｐ２１ 蛋白和ＨＳＰ２７的水平的变化对于焦炉工人肺癌的早期监护具有重要意义
Objective To find early monitoring indicators of lung cancer in coke oven workers exposed to coke oven fumes. Methods Dot blot was used to detect the levels of ras gene product p21 protein and HSP27 and HSP70 in 56 coke oven workers and 32 control groups. Results The p21 protein level in coke oven workers’ serum was significantly higher than that in the control group (P < 0-01), and the positive rate was 35-7 %, which was significantly higher than that of the control group (12-5 %, P <0-05); The analysis shows that there is a significant correlation between the coke oven worker’s p21 level and the worker’s length of service (P<0-001). At the same time, the HSP27 level in coke oven workers was also significantly higher than that in the control group (P<0-05). There was no significant difference in HSP70 level between the two groups. Conclusion It is speculated that the changes of serum levels of p21 protein and HSP27 are important for the early monitoring of lung cancer in coke oven workers.