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目的 从临床观察和动物实验两方面研究草果知母汤 (CGZMT)的抗疒间 性。方法 通过对 17例癫疒间患儿药效学观察 ,评价CGZMT的临床疗效。利用小鼠最大电休克发作 (MES)模型、大鼠听源性发作 (AGS)癫疒间模型、小鼠戊四唑阈值发作试验 (MST) ,研究CGZMT的抗疒间 性。结果 临床观察显示 :总有效率 6 4 7% ,单服中药与中西药合用的抗疒间 性无显著性差异 (P >0 0 5 )。CGZMT对小鼠MES的拮抗作用及用药 2周对大鼠AGS的抗疒间 性均与苯巴比妥 (PB)相似 (P >0 0 5 ) ;对MST疗效弱 ,但与氯硝西泮 (CZP)合用抗惊厥率达 85 % ,疗效优于模型组 (P <0 0 1)。结论 CGZMT有肯定的抗疒间 性 ,对强直 阵挛性发作疗效优于失神发作 ,无明显毒副作用。对于失神发作 ,CGZMT与CZP有较强的协同作用
Objective To study the anti-spasmodicity of Caoguo Zhimu Decoction (CGZMT) from clinical observation and animal experiment. Methods The clinical efficacy of CGZMT was evaluated by pharmacodynamic observation of 17 children with epilepsy. The maximal electroconvulsive seizure (MES) model in mice, the auditory seizure (AGS) epileptic seizure model in rats, and the mouse pentylenetetrazol threshold seizure test (MST) were used to study the anti-spasmodicity of CGZMT. Results Clinical observations showed that the total effective rate was 64.7%, and there was no significant difference in the antispasmodic effect between single Chinese medicine and Chinese and Western medicines (P > 0.05). The antagonism of CGZMT on mouse MES and the antispasmodic effect of AGS on rats for 2 weeks were similar to that of phenobarbital (P > 0.05). The effect on MST was weak, but with clonazepam. (CZP) combined anticonvulsant rate of 85%, the curative effect is better than the model group (P <0 01). Conclusions CGZMT has a positive antispasmodic effect and is superior to an absence seizure in the treatment of tonic spasmodic seizures without obvious side effects. For absence seizures, CGZMT and CZP have a strong synergy