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药物耐受性是肿瘤化疗面临的主要问题之一 ,其原因是肿瘤细胞的异质性、遗传不稳定和突变率高。血管内皮细胞均质 ,遗传稳定 ,突变率较低 ,是较为理想的靶细胞。控制肿瘤内部血管生成 ,就能抑制肿瘤生长和肿瘤转移灶的形成。经过近 2 0年的努力 ,有关研究已取得了重大进展。血
Drug resistance is one of the major problems in cancer chemotherapy, due to the heterogeneity of tumor cells, genetic instability and high mutation rate. Homogeneous vascular endothelial cells, genetic stability, mutation rate is low, is an ideal target cells. Control of tumor internal angiogenesis, can inhibit tumor growth and tumor metastasis formation. After nearly 20 years of hard work, great progress has been made in relevant research. blood