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短期吸入NO可降低ARDS病人的肺血管阻力,改善氧合。但尚无关于ARDS病人长期吸入NO效果的资料。为此,作者观察了吸入NO 1h和72h的效应,并与常规治疗对比。 40例ARDS病人均符合下列诊断标准:急性呼衰需机械通气;X线片显示两肺浸润;PaO_2/FiO_2<150;原发病除外左房高压或左心衰,或PCWP≤2.4kPa。孕妇和恶性肿瘤病人除外。病人随机分为两组,Ⅰ组常规治疗,Ⅱ组常规治疗加0.22～0.89μmol/LNO吸入72h。在此期间调节FiO_2使PaO_2在7.3～8.6kPa或
Short-term inhaled NO can reduce ARDS patients pulmonary vascular resistance, improve oxygenation. However, there is no data on the long-term inhalation of NO in patients with ARDS. For this reason, the authors observed the effects of NO 1h and 72h inhalation, compared with conventional treatment. 40 cases of ARDS patients were in line with the following diagnostic criteria: acute respiratory failure required mechanical ventilation; X-ray film showed two lung infiltrates; PaO_2 / FiO_2 <150; except primary left atrial hypertension or left heart failure, or PCWP ≤ 2.4kPa. Except for pregnant women and malignant tumors. Patients were randomly divided into two groups, Ⅰ conventional treatment, Ⅱ group conventional treatment plus 0.22 ~ 0.89μmol / LNO inhalation 72h. During this period adjust FiO_2 PaO_2 at 7.3 ~ 8.6kPa or