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A novel approach to the synthesis of 4-phenylethynylphthalic anhydride has been described.The target compound was synthesized by Pd/Cu catalyzed Sonogashira coupling reaction between phenylacetylene and 4-bromophthalic acid which was for the first time employed as start material,followed by dehydration of 4-phenylethynylphthalic acid.Compared with traditional synthetic routes,this method provides several advantages such as readily available raw materials,convenient manipulation and high yield.The products were characterized by IR,~1H NMR,~(13)C NMR,MS and elemental analysis,respectively.
A novel approach to the synthesis of 4-phenylethynylphthalic anhydride has been described. The target compound was synthesized by Pd / Cu catalyzed Sonogashira coupling reaction between phenylacetylene and 4-bromophthalic acid which was for the first time employed as start material, followed by dehydration of 4-phenylethynylphthalic acid. Compared with traditional synthetic routes, this method provides several advantages such as readily available raw materials, convenient manipulation and high yield. These products were characterized by IR, ~ 1H NMR, ~13C NMR, MS and elemental analysis, respectively.