本文共观测了66例糖尿病患者血清骨钙素(BGP)、甲状旁腺激素(PTH)、降钙素(CT)、碱性磷酸酶(AKP)及血钙(Ca)、磷(P)等指标。与正常对照组比较,糖尿病各组中血清BGP水平明显下降;血清PTH水平及AKP活性明显升高;血清CT,Ca、P水平正常。糖尿病患者骨密度(BMD)与血清BGP呈正相关,与年龄、血清PTH、糖化血红蛋白(HbA1c)、空腹血糖(FBG)呈负相关,与病程等无相关性。表明成骨细胞活性下降,骨形成减少,继发性甲旁亢等是造成糖尿病性骨质疏松的重要原因。 A total of 66 diabetic patients with serum BGP, PTH, CT, AKP and Ca, P, etc. were observed in this study. index. Compared with the normal control group, the level of BGP in serum of diabetic group decreased significantly, serum PTH level and AKP activity increased significantly, and serum CT, Ca, P levels were normal. The BMD of diabetic patients was positively correlated with serum BGP, but negatively correlated with age, serum PTH, HbA1c, fasting blood glucose (FBG), and had no correlation with the course of disease. That osteoblast activity decreased bone formation, secondary hyperparathyroidism is caused by an important reason for diabetic osteoporosis.