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目的探讨肺鳞癌组织中淋巴管分布和存在状态及可能的原因。方法肺鳞癌组40例,肺炎性假瘤组10例。用LYVE-1/CD34免疫组化双染色法区分淋巴管和血管并观察淋巴管内皮透明质酸受体-1(LYVE-1)蛋白表达的情况。结果1.肺鳞癌组织周边部淋巴管密度远大于内部和炎性假瘤组织。2. 网状淋巴管肺鳞癌组织周边部远大于肺鳞癌组织内部及炎性假瘤组织。塌陷淋巴管肺鳞癌组织周边部密度小于肺鳞癌组织内部而大于炎性假瘤组织,塌陷淋巴管肺鳞癌组织内部密度远大于炎性假瘤组织;3.在肺鳞癌组织周边部:单腔淋巴管密度远大于塌陷淋巴管密度和网状淋巴管密度,塌陷淋巴管密度小于网状淋巴管密度。在肺鳞癌组织内部:单腔淋巴管密度小于塌陷淋巴管密度而大于网状淋巴管密度,塌陷淋巴管密度大于网状淋巴管密度。在炎性假瘤组织:单腔淋巴管密度远大于塌陷淋巴管密度和网状淋巴管密度。结论肺鳞癌组织淋巴管生成主要在周边部,肺鳞癌组织内部淋巴管塌陷明显增多导致的淋巴管无功能状态可能主要是由于高间质压引起的。
Objective To investigate the distribution and existing status of lymphatic vessels in lung squamous cell carcinoma and possible causes. Methods Forty lung squamous carcinoma patients and 10 pulmonary inflammatory pseudotumor patients. The lymphatic vessels and blood vessels were differentiated by LYVE-1 / CD34 double staining, and the expression of LYVE-1 protein in lymphatic vessels was observed. Results 1. The density of lymphatic vessels around the lung squamous cell carcinoma tissue was much larger than that of the internal and inflammatory pseudotumor tissues. The reticular lymphatic squamous cell carcinoma of the perimeter is much larger than the squamous cell carcinoma of the lung tissue and inflammatory pseudotumor. The density of peripheral lymph nodes in squamous cell carcinoma of lymphatic vessels was less than that of inflammatory pseudotumor tissues in squamous cell carcinoma of lung squamous cell carcinoma and the density of squamous cell carcinoma in collapsed lymphatic vessels was much larger than that in inflammatory pseudotumor tissues.3. : Single lumen density is far greater than the collapsed lymphatic vessel density and reticular lymphatic vessel density, collapsed lymphatic vessel density is less than the reticular lymphatic vessel density. In squamous cell lung squamous cell carcinoma, the density of single-lumen lymphatic vessels is smaller than that of collagenous lymphatic vessels and greater than that of reticular lymphatic vessels. The density of collapsed lymphatic vessels is larger than that of reticular lymphatic vessels. In inflammatory pseudotumor tissue: the density of single-lumen lymphatic vessels is much greater than that of collapsed lymphatic vessels and reticular lymphatic vessels. Conclusions Lymphangiogenesis in squamous cell carcinoma of the lung is mainly caused by lymphatic collapse, which is mainly caused by lymphatic collapse in the peripheral part of lung squamous cell carcinoma. The non-functional state of lymphatic vessels may be mainly caused by high interstitial pressure.