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肺动脉高压是一种慢性致命性疾病,以肺动脉压力和肺血管阻力不断升高为主要特征,最终导致右心衰竭而死亡。一氧化氮(NO)是血管内皮细胞产生的一种血管活性物质,具有舒张血管平滑肌细胞的作用。吸入NO能选择性作用于肺血管,降低肺动脉压力和肺血管阻力。近年来,NO已越来越多地应用于肺动脉高压的治疗,特别是对先天性心脏病合并肺动脉高压患者术中和术后以及新生儿持续肺动脉高压有显著作用。
Pulmonary hypertension is a chronic, fatal disease characterized by an increase in pulmonary artery pressure and pulmonary vascular resistance, which eventually leads to the death of right heart failure. Nitric oxide (NO) is a vasoactive substance produced by vascular endothelial cells and plays a role in relaxing vascular smooth muscle cells. Inhaled NO can selectively act on the pulmonary blood vessels, reduce pulmonary artery pressure and pulmonary vascular resistance. In recent years, NO has been increasingly used in the treatment of pulmonary hypertension, especially in patients with congenital heart disease complicated pulmonary hypertension intraoperative and postoperative as well as neonatal persistent pulmonary hypertension have a significant role.