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美国疾病控制和预防中心（CDC）和印度的研究者研制了一种疟疾疫苗,此疫苗能攻击处于复杂生活周期各期的疟原虫。研究者构建了一种能编码12个B细胞表位、6个T细胞表位和3个细胞毒性T淋巴细胞表位的合成基因,这些表位来自9个期特异性疟原虫抗原。疫苗与不同佐剂一起接种。家兔间隔3周肌注4剂疫苗,疫苗能诱生高水平和持久的抗体应答,第4剂后达到高峰。14周内抗体一直维持高水平,从13周到50周抗体水平下降10～15倍。
The Centers for Disease Control and Prevention (CDC) and Indian researchers have developed a malaria vaccine that attacks malaria parasites in stages of a complex life cycle. The researchers constructed a synthetic gene that encodes 12 B-cell epitopes, 6 T-cell epitopes and 3 cytotoxic T lymphocyte epitopes from nine stage-specific Plasmodium antigens. Vaccines were vaccinated with different adjuvants. The rabbits were intramuscularly injected with 4 doses of vaccine at 3 weeks intervals. The vaccine induced high-level and long-lasting antibody responses and peaked after the 4th dose. Antibody levels remain high for 14 weeks, with antibody levels decreasing 10-15 fold from 13 weeks to 50 weeks.