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目的 探讨不同冠状动脉粥样硬化病变患者中血浆血管性血友病因子 (vWF)及α 颗粒膜蛋白 (GMF 14 0 )水平的临床意义。方法 74例接受选择性冠状动脉造影的患者根据冠脉硬化病变形态分为S组 (光滑斑块组 )和C组 (复杂病变斑块组 )。C组患者根据病变支数分为Ⅰ组 (单支病变组 ) ;Ⅱ组 (双支病变组 )和Ⅲ组 (3支病变组 )。根据狭窄段数将C组患者分为x组 (≤ 3段组 ) ;y组 (≥ 4段组 )。所有患者于冠脉造影前采血测定血浆vWF、GMP 14 0水平。结果 ①C组血浆、vWF、GMP 14 0水平显著高于S组。②Ⅲ组血浆vWF、GMF 14 0水平显著高于Ⅰ、Ⅱ组 ,Ⅱ组血浆vWF水平显著高于Ⅰ组。③y组血浆vWF、GMP 14 0水平显著高于x组。结论 ①冠脉造影表现为复杂形态病变者属于高危不稳定性病变。②血浆vWF、GMP 14 0水平可作为判断冠状动脉粥样硬化病变的程度、范围及是否存在不稳定病变的间接指标。
Objective To investigate the clinical significance of vWF and GMF 14 0 in patients with different coronary atherosclerotic lesions. Methods 74 patients undergoing selective coronary angiography were divided into S group (smooth plaque group) and C group (complex lesion plaque group) according to the pathological changes of coronary artery. Patients in group C were divided into group Ⅰ (single vessel lesion group), group Ⅱ (double vessel lesion group) and group Ⅲ (3 vessel lesion group) according to the number of lesions. Patients in group C were divided into group x (≤ 3 groups) and group y (≥ 4 groups) according to the number of stenosis. All patients were collected before coronary angiography vWF plasma, GMP 14 0 levels. Results ① The levels of plasma, vWF and GMP 14 0 in group C were significantly higher than those in group S. ② The vWF and GMF 14 0 levels in group Ⅲ were significantly higher than those in group Ⅰ and Ⅱ, and the plasma vWF levels in group Ⅱ were significantly higher than those in group Ⅰ. ③ The plasma levels of vWF and GMP 14 0 in group y were significantly higher than those in group x. Conclusion ① Coronary angiography showed complex morbidities as high-risk and unstable lesions. ② Plasma vWF, GMP 14 0 levels can be used as indirect indicators to determine the extent of coronary atherosclerotic lesions, extent and presence of unstable lesions.