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目的 探讨胃癌患者外周血中白细胞介素２ （ＩＬ２）、白细胞介素２ 受体（ｓＩＬ２Ｒ） 水平及ＣＤ２５ 表达三者手术前后的动态变化情况和相互关系，以及前列腺素Ｅ２（ＰＧＥ２） 与ＩＬ２／ＩＬ２Ｒ系统的关系。方法 分别采用ＥＬＩＳＡ法、１２５ＩＲＩＡ法及免疫荧光法对５０ 例胃癌患者手术前后外周血中ＩＬ２、ｓＩＬ２Ｒ、ＰＧＥ２ 水平及ＣＤ２５ 表达进行检测。结果 胃癌患者手术前后外周血中ＩＬ２ 水平及ＣＤ２５ 表达均低于对照组，而ｓＩＬ２Ｒ与ＰＧＥ２ 水平均高于对照组；切除肿瘤后ＩＬ２ 水平及ＣＤ２５ 表达较术前升高，而ｓＩＬ２Ｒ及ＰＧＥ２ 水平较术前下降；６ 例术后发生肿瘤转移或复发的患者中，再次出现ＩＬ２ 水平及ＣＤ２５ 表达下降，而ｓＩＬ２Ｒ及ＰＧＥ２ 水平上升，胃癌患者术前ＩＬ２ 水平与术前ＰＧＥ２ 水平呈显著负相关，术前ｓＩＬ２Ｒ水平与ＩＬ２ 水平亦呈显著负相关。结论 ＰＧＥ２ 与ｓＩＬ２Ｒ 参与了胃癌患者术前存在的免疫抑制过程。非甾体抗炎药（ＮＳＡＩＤ）与外源性ＩＬ２ 联合应用以预防胃癌转移或复发理论上具有可行性。
Objective To investigate the dynamic changes and correlations of interleukin-2 (IL-2), interleukin-2 receptor (sIL-2R) levels and CD25 expression in peripheral blood of patients with gastric cancer before and after surgery, and to discuss the relationship between prostaglandin E2 (PGE2) ) Relationship with the IL-2/IL-2R system. Methods The levels of IL-2, sIL-2R, PGE2 and CD25 in peripheral blood of 50 gastric cancer patients before and after surgery were measured by ELISA, 125I-RIA and immunofluorescence. Results The levels of IL-2 and CD25 in peripheral blood of gastric cancer patients before and after operation were lower than those in the control group. The levels of sIL-2R and PGE2 were higher than those in the control group. The levels of IL-2 and CD25 after tumor removal were higher than those before surgery. The levels of sIL2R and PGE2 decreased compared with preoperative levels; in patients with metastasis or recurrence after surgery, the levels of IL 2 and CD25 decreased again, while the levels of sIL2R and PGE2 increased. Preoperative IL in patients with gastric cancer The level of 2 was significantly negatively correlated with preoperative PGE2 levels, and there was a significant negative correlation between preoperative sIL 2R levels and IL 2 levels. Conclusion PGE2 and sIL2R are involved in the preoperative immunosuppression of gastric cancer patients. The combination of non-steroidal anti-inflammatory drugs (NSAIDs) and exogenous IL-2 to prevent metastasis or recurrence of gastric cancer is theoretically feasible.